Who is a candidate for screening inherited thrombophilia?

Candidates for screening inherited thrombophilia are typically those who have a personal history of venous thromboembolism (VTE) without recent identifiable risk factors. A personal history of VTE indicates that the individual already has a clotting issue, and when this occurs in the absence of recent risk factors—such as surgery, pregnancy, or prolonged immobility—it raises suspicion for an underlying inherited condition that predisposes them to thrombosis.

In such cases, screening may be warranted to identify any genetic factors that could put them at risk for future VTE events, allowing for appropriate management such as thromboprophylaxis or lifestyle adjustments. Identifying these conditions can help in the overall care of the patient and their potential future pregnancies or surgeries.

The other options do not fit the criteria for screening as effectively, as they either involve individuals without personal histories of VTE or those with only familial histories, which do not warrant screening unless the individual themselves has experienced a thrombosis.