Which platelet antigen are antibodies commonly associated with in NAIT?

Neonatal alloimmune thrombocytopenia (NAIT) occurs when a mother produces antibodies against her fetus's platelet antigens, leading to low platelet counts in the newborn. The antibodies that cause NAIT are predominantly directed against specific platelet glycoproteins.

The correct association regarding NAIT antibodies is with Glycoprotein IV, also known as CD36. This glycoprotein serves as a receptor on platelets and plays a vital role in platelet function. In cases of NAIT, antibodies against CD36 can lead to significant antibodies binding to the fetal platelets derived from the father, who carries the antigen, resulting in a decrease in the platelet count in the neonate.

Although other glycoproteins such as IIb/IIIa, Ib/IX, and V are relevant in platelet biology and can involve in different immune responses, they are not commonly associated with the antibody-mediated response seen in NAIT. Glycoprotein IIb/IIIa is primarily involved in platelet aggregation, while Ib/IX plays a role in adhesion and stability of platelet interactions with the vascular endothelium. Glycoprotein V does not have a significant established connection with NAIT. Thus, the specific antibodies against Glycoprote