Which of the following is commonly advised for managing sickle cell disease during pregnancy?

Folic acid supplementation is commonly advised for managing sickle cell disease during pregnancy due to the increased metabolic demands and the necessity for higher red blood cell production. During pregnancy, a woman's body undergoes significant changes, including a substantial increase in blood volume and the need for additional hematopoiesis (the formation of blood cells) to support the developing fetus. Women with sickle cell disease, who are already at risk for anemia due to the hemolytic nature of their condition, may require even more folic acid to help prevent megaloblastic anemia and ensure proper fetal development.

Folic acid assists in DNA synthesis and is crucial for the creation of new red blood cells, making it essential for women with sickle cell disease throughout their pregnancy. This supplementation can help mitigate complications related to anemia, which can be exacerbated during pregnancy due to increased blood volume and the demands on the body.

Other options, while potentially relevant to general obstetric care, do not address the specific needs associated with sickle cell disease in pregnancy. Regular pelvic exams are important for general obstetric care but do not specifically manage sickle cell disease. High iron dietary intake is not advisable for patients with sickle cell disease unless there is clear evidence of iron deficiency, as