Which condition is NOT typically included in carrier screening for Ashkenazi Jews?

Carrier screening for Ashkenazi Jews is designed to identify individuals who are carriers of specific genetic disorders that are more prevalent in this population. Tay-Sachs disease and Canavan disease are both autosomal recessive disorders that occur at heightened rates among Ashkenazi Jews, making them important targets for carrier screening in this group. Similarly, cystic fibrosis, while more common in Caucasian populations, is also included in screening panels due to its significant implications for health.

Sickle cell disease, however, is primarily associated with African and Mediterranean ancestry and is less commonly found in the Ashkenazi Jewish population. As a result, it is not typically included in the standard carrier screening for Ashkenazi Jews since the prevalence of the carrier state for this condition is relatively low in this particular group. The intention of these screenings is to focus on conditions that have the highest likelihood of being present in the population being tested.