Which clinical finding is associated with congenital syphilis?

Saddle nose is a clinical finding associated with congenital syphilis, specifically resulting from the damage inflicted on the nasal cartilage due to the infection. This condition leads to a characteristic flattening of the nasal bridge, giving it a "saddle" appearance. The presence of saddle nose is a known complication of congenital syphilis and is part of a constellation of signs that may appear in an infant born to a mother with untreated syphilis during pregnancy.

While other findings like maculopapular rash, lymphadenopathy, and chorioretinitis can occur in congenital syphilis, they are not as distinctive as saddle nose. Maculopapular rash can also be seen in other infections, lymphadenopathy is a general feature of many infectious processes, and chorioretinitis is more commonly related to other congenital infections like cytomegalovirus (CMV). Thus, saddle nose is a unique and identifying feature specifically linked to congenital syphilis.