When does the closure of the neural tube typically occur?

The closure of the neural tube typically occurs around 3 to 4 weeks after fertilization, which aligns with the established timeline of embryonic development. Specifically, neural tube formation begins around the third week of gestation, and the closure occurs by the end of the fourth week. This process is critical as it forms the basis for the central nervous system, including the brain and spinal cord. Failure of the neural tube to close properly can lead to significant congenital malformations, such as spina bifida or anencephaly. Understanding this timeline is crucial for clinicians monitoring fetal development and counseling patients regarding potential risks associated with neural tube defects.