What significant finding is often seen with Club feet in relation to Trisomy 18?

The significant finding associated with club feet in the context of Trisomy 18 is rocker bottom feet. Trisomy 18, also known as Edwards syndrome, is characterized by various physical anomalies, including those affecting the feet. Rocker bottom feet refer to a specific foot deformity that features a prominent bulbous heel and a concave sole, creating a rocking chair-like appearance. This finding is important clinically as it can be an identifying feature in Pre-natal screenings or examinations for trisomy conditions, including Trisomy 18.

While the other findings related to Trisomy 18, such as increased amniotic fluid, single umbilical artery, and holoprosencephaly, are noteworthy in the broader context of the syndrome, they are not directly correlated with club feet. Rocker bottom feet is particularly notable and represents a classic physical sign that can aid healthcare providers in identifying and managing conditions associated with Trisomy 18. Understanding these associations is vital for diagnosis and subsequent family counseling regarding the implications of these congenital anomalies.