What major side effect is associated with Vancomycin administration?

Vancomycin is an antibiotic that is primarily used to treat serious infections caused by Gram-positive bacteria, particularly in patients who are allergic to penicillin. One of the major side effects associated with its administration is Red Man syndrome. This reaction occurs due to the rapid infusion of the drug and is characterized by flushing of the skin, particularly on the upper body, along with potentially itching, and sometimes hypotension.

Red Man syndrome is not an allergic reaction but rather a direct effect of vancomycin on mast cells, leading to histamine release. It is important to recognize this reaction because it impacts how vancomycin is administered; slowing the infusion rate can help mitigate the symptoms associated with this syndrome. Knowing that this side effect can occur helps practitioners manage the administration of vancomycin more effectively and ensures patient comfort and safety.

While nephrotoxicity and allergic reactions can also be associated with vancomycin, they are not as immediate or characteristic as Red Man syndrome. Severe headache is not a well-documented side effect of vancomycin. Understanding the nature of Red Man syndrome specifically highlights the need for careful infusion practices when administering vancomycin.