What major risk is associated with a macrosomic infant weighing over 5000 grams?

The increased stillbirth risk associated with macrosomic infants, particularly those weighing over 5000 grams, is well-supported by evidence highlighting the complications that can arise during pregnancy and delivery. Macrosomia can lead to a variety of fetal and maternal challenges, including difficulties in fetal monitoring and increased chances of labor complications, which can contribute to adverse outcomes such as stillbirth.

Macrosomic infants may experience altered placental function, which can affect the oxygen and nutrient supply to the fetus. This can lead to a higher likelihood of in utero distress or fetal demise as pregnancy progresses, especially if other factors such as gestational diabetes or hypertension are also present. Thus, the association between macrosomia and an increased risk of stillbirth is a critical consideration during prenatal care and delivery planning.

Other options, while they may relate to pregnancy outcomes, do not have the same direct correlation as stillbirth risk does with macrosomic infants. For example, maternal depression may not be specifically linked to the infant's size, while preterm labor is generally concerned with lower birth weights, and low birth weight is inherently opposite to the situation being discussed. Understanding these risks is essential for appropriate monitoring and management in pregnancies involving suspected macrosomia.