What is the treatment for primary, secondary, or early latent syphilis?

The treatment for primary, secondary, or early latent syphilis is benzathine penicillin G at a dosage of 2.4 million units administered intramuscularly as a single dose. This treatment is effective because benzathine penicillin G is a long-acting formulation of penicillin that provides sustained levels of the drug in the body, which is critical for eradicating Treponema pallidum, the bacteria responsible for syphilis.

The single-dose treatment is particularly suited for these early stages of syphilis, making it a straightforward and effective option for management. It is also recommended by public health guidelines due to its efficacy and safety profile, aligning with practices aimed at reducing the risk of transmission and preventing complications associated with untreated syphilis.

Other treatment options, such as intravenous penicillin G, doxycycline, or ceftriaxone, are not the first line for initial stages of syphilis. Intravenous penicillin G is typically reserved for more severe cases, such as neurosyphilis or treatment-resistant cases, while doxycycline is an alternative treatment for those allergic to penicillin, yet it requires a longer duration of treatment and is not as effective in the early stages. Ceftriax