What is the recommended weekly dose of 17 hydroxyprogesterone caproate during pregnancy?

The recommended weekly dose of 17 hydroxyprogesterone caproate during pregnancy is 250 mg administered intramuscularly (IM). This medication is primarily used to reduce the risk of preterm birth in women with a history of spontaneous preterm delivery. The dosing regimen has been established through clinical trials that demonstrated its efficacy in decreasing the rates of premature labor and improving neonatal outcomes.

200 mg IM is not a standard dose in this context; therefore, dosing below or above the recommended amount may not provide the intended benefits. The use of 250 mg aligns with clinical guidelines and is considered an optimal balance for achieving therapeutic effects while maintaining safety for the patient.