What is the recommended dose of Cefazolin for patients weighing over 120 kg undergoing a cesarean section?

The recommended dose of Cefazolin for patients weighing over 120 kg undergoing a cesarean section is 3 grams. This dosing recommendation is based on the need to ensure adequate antibiotic coverage for surgical prophylaxis in individuals with higher body weights, which increases the volume of distribution and may require a higher dose to achieve effective plasma concentrations.

In surgical settings, particularly for cesarean deliveries, sufficient antibiotic prophylaxis is crucial to minimize the risk of postoperative infections. Standard dosing guidelines typically suggest 1 gram for patients under 120 kg, but as weight increases, the expected increased tissue penetration and pharmacokinetics necessitate higher dosing to ensure that therapeutic levels are reached and maintained throughout the procedure.

Additionally, studies support the use of higher Cefazolin doses as appropriate for patients of higher weight categories to optimize infection prevention outcomes. This balancing of antibiotic efficacy and safety is critical in surgical practices, particularly in obstetrics where maternal and neonatal outcomes are of paramount importance. Thus, the recommendation of 3 grams specifically reflects the adjustment needed for patients exceeding 120 kg to maintain effectiveness in preventing post-surgical infections.