What is the most common clinical presentation of myasthenia gravis?

Myasthenia gravis is characterized primarily by muscle weakness and fatigability. This condition is an autoimmune disorder where the body produces antibodies that attack the acetylcholine receptors at the neuromuscular junction, leading to decreased transmission of nerve impulses to muscles. Patients typically experience symptoms that fluctuate in intensity, often worsening with activity and improving with rest. The weakness may affect various muscle groups, including those responsible for eye movement (resulting in ptosis or diplopia), facial expression, and even respiration.

While joint pain, rapid heart rate, and numbness in extremities are common symptoms associated with other conditions, they are not characteristic of myasthenia gravis. Joint pain and stiffness could indicate inflammatory arthritis, rapid heart rate might suggest a cardiovascular issue or an anxiety disorder, and numbness in the extremities could be related to neurological issues such as peripheral neuropathy or multiple sclerosis. Therefore, the distinct symptom of muscle weakness and fatigability is what makes it the most recognized clinical presentation of myasthenia gravis.