What is the increase in fibrinogen levels from one unit of fresh frozen plasma?

When administering one unit of fresh frozen plasma (FFP), it is important to understand its effects on fibrinogen levels, which is a critical factor in the coagulation cascade. Fresh frozen plasma contains all the coagulation factors, including fibrinogen, and is used to provide these factors to patients who may be deficient, such as in cases of massive transfusions, liver disease, or disseminated intravascular coagulation (DIC).

Research indicates that one unit of FFP typically raises the fibrinogen level in an adult by approximately 10 mg/dL. This increase is significant for managing coagulopathy and ensuring adequate hemostatic function in various clinical scenarios. This knowledge is pivotal for obstetricians who may encounter bleeding disorders during pregnancy or childbirth, making it essential to accurately assess the expected impact of FFP on fibrinogen levels.

An understanding of the specific increase helps clinicians anticipate the effects of transfusion and manage their patients' coagulation status effectively. Recognizing that the expected increase is around 10 mg/dL guides clinical decision-making and enables practitioners to address coagulopathic situations with precision.