What is a potential complication of Prostaglandin E1 administration?

Prostaglandin E1, commonly used for cervical ripening and induction of labor, can lead to uterine tachysystole, which is defined as an excessive frequency of uterine contractions. When contractions are too frequent or intense, it can result in a compromised fetal heart rate (FHR) pattern due to insufficient uteroplacental blood flow, potentially causing fetal distress characterized by changes in the FHR, such as decelerations.

Uterine tachysystole is particularly concerning as it may significantly affect fetal well-being, warranting close monitoring of both uterine activity and fetal heart rate during administration. In cases where uterine contractions become excessively frequent, the risk for complications such as uterine rupture or severe fetal distress increases, which further emphasizes the need for vigilant fetal monitoring when using prostaglandins.

The understanding of uterine tachysystole's impact on FHR is critical for practitioners to manage labor effectively and to ensure maternal and fetal safety during induction with Prostaglandin E1.