What is a common side effect of antiviral medications used for HSV?

Antiviral medications used for herpes simplex virus (HSV) infections, such as acyclovir or valacyclovir, frequently report headaches as a common side effect. This occurrence is generally related to the medication's effects on the central nervous system or the body’s responses to treatment. Patients may experience pain or discomfort as their body reacts to the viral suppression caused by the antivirals.

While other side effects may arise with these medications, headaches are among the most reported in clinical settings. Diarrhea, while it can occur, is not as common as headaches in relation to these specific antiviral treatments. Weight gain is not typically associated with antiviral medications for HSV. Similarly, insomnia may occur, but it is not as prevalent in the literature as headaches. Therefore, headaches stand out as a more frequent and notable side effect in patients undergoing antiviral therapy for HSV.