What findings are indicative of Turner Syndrome in a first-trimester screen?

Turner Syndrome, a condition caused by the absence of all or part of a second sex chromosome, can be identified through abnormalities in certain biomarkers during a first-trimester screen. The correct choice highlights two significant findings: an increased nuchal translucency (NT) measurement and low beta-human chorionic gonadotropin (beta HCG) levels.

The increased NT indicates a greater risk for chromosomal abnormalities, including Turner Syndrome, as fetuses with this condition often present with elevated NT due to lymphatic issues that can result in fluid accumulation. Low levels of beta HCG in this context further suggest an increased risk for aneuploidy. In Turner Syndrome, the lack of a second sex chromosome affects development, leading to characteristic ultrasound findings that include a thickened NT.

In contrast, other options present scenarios that either indicate normal or less concerning findings, which would not typically suggest Turner Syndrome. Thus, understanding the significance of increased NT alongside low beta HCG offers a clearer risk profile for Turner Syndrome in early pregnancy screenings, making this the correct answer.