How soon after delivery should RhIg (Rhogam) be administered?

Rh immunoglobulin (often referred to as Rhogam) is administered to Rh-negative women who deliver an Rh-positive infant. This is crucial in preventing Rh immunization, which can lead to hemolytic disease of the newborn in future pregnancies.

The correct timing for administering RhIg is within 72 hours postpartum. This timing is essential because the earlier the treatment is given, the more effective it is at neutralizing any Rh-positive fetal red blood cells that may have entered the maternal circulation during delivery. Administering RhIg within this timeframe helps to prevent the mother's immune system from producing antibodies against Rh-positive blood, which is vital for the health of any future pregnancies.

Although RhIg can be given up to 72 hours after delivery, giving it any later would risk the chance that sensitization has already occurred, making timely intervention critical. This guideline is supported by professional organizations, including the American College of Obstetricians and Gynecologists (ACOG), which recommends that RhIg administration should happen as soon as possible within this window, but preferably within the first 48 hours to optimize outcomes.