What is the maximum time frame after delivery within which RhIg (Rhogam) can be administered for some protection?

Rh immunoglobulin (RhIg), commonly known as RhoGAM, is a critical preventive treatment for Rh-negative mothers who have given birth to an Rh-positive baby. The timely administration of RhIg is essential to prevent Rh sensitization in future pregnancies.

Administering RhIg ideally occurs within 72 hours of delivery, but it can be administered later, providing some protection against sensitization. The maximum time frame for administering RhIg to still confer protection is up to 14 days postpartum. By this point, while the efficacy begins to decline, administering RhIg can still mitigate the risk of Rh immunization, helping to prevent hemolytic disease of the newborn in subsequent pregnancies.

Thus, the optimal window for RhIg administration extends to 14 days after delivery, supporting maternal well-being and subsequent fetal health in future pregnancies. This timeframe aligns with clinical guidelines that emphasize the importance of prompt intervention following delivery to safeguard against Rh sensitization.